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===under info was translated buy computer===
Epigenetic activation or inactivation of genes plays a critical role in many important human diseases, especially in cancer. A major mechanism for epigenetic inactivation of the genes is methylation of CpG islands in genome DNA caused by DNA methyltransferases. Histone methyltransferases (HMTs) control or regulate DNA methylation through chromatin-dependent transcriptional repression or activation. HMTs transfer 1-3 methyl groups from S-adenosyl-L-methionine to the lysine and arginine residues of histone proteins. PR-SET7, SET9, SUV4.20h, and ASH1are histone methyltransferases that catalyze methylation of histone H4 at lysine 20 (H4K20) in mammalian cells. H4K20 mono-methylation is involved in the maintenance of the proper higher order structure of DNA and is consequently essential for chromosome condensation, it also functions in gene silencing. The H4K20 mono-methylation can also be changed by inhibition or activation of HMTs, making quantitative detection of mono-methyl histone H4K20 useful in developing a better understanding of epigenetic regulation of gene activation/repression and for developing HMT-targeted drugs. The Mono-Methyl Histone H4K20 Quantification Kit (Colorimetric) provides a tool for measuring Mono-methylation of histone H4K20.
https://www.creativebiomart.net/mono-methyl-histone-h4k20-quantification-kit-colorimetric-463379.htm
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