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Cat.No.:	Kit-0540
Product Overview:	MAPKAP-kinase 2 (Human) Assay/Inhibitor Screening Assay Kit is a single-site, non-quantitative immunoassay for MAPKAP-kinase 2 activity. Plates are pre-coated with a substrate corresponding to recombinant LSP1 (Leukocyte Specific Protein), which contains a serine residue that are phosphorylated by MAPKAP-kinase 2 (MAPK-activated protein kinase 2). The detector antibody specifically detects only the phosphorylated form of serine-204 on LSP1.
Description:	Aurora-A is a key member of a closely related subgroup of serine/threonine kinases that belongs to the Drosophila aurora and Saccharomyces cerevisiae Ipl1 kinase family, and both are essential for chromosome segregation and centrosome functions. Aurora-A kinase has been shown to contribute to oncogenic transformation and is frequently overexpressed and amplified in many human tumor types. It has been reported that amplification of Aurora-A in approximately 12% of primary breast tumors, as well as in breast, ovarian, colon, prostate, neuroblastoma, and cervical cancer cell lines. Additionally, high expression of Aurora-A mRNA was detected in tumor cell lines without evidence of gene amplification. Ectopic expression of Aurora-A in mouse NIH 3T3 cells led to the appearance of abnormal centrosome number (amplification) and transformation in vitro. Finally, overexpression of Aurora-A in near-diploid human breast epithelial cells revealed similar centrosome abnormality, as well as induction of aneuploidy. These findings suggested that Aurora-A is a critical kinase-encoding gene, whose overexpression leads to centrosome amplification, chromosomal instability, and transformation in mammalian cells.

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