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https://www.creativebiomart.net/ctla4b7-1biotinylated-inhibitor-screening-assay-kit-465597.htm
| Cat.No.: | Kit-1712 |
| Product Overview: | The activation of native T cells requires two signals, the specific T cell receptor recognition of MHC/Antigen on the surface of the antigen-presenting cell (APC), and the binding of B7-1 (CD80) ligand on the APC with the CD28 receptor on the T cell surface. Conversely, binding of CTLA4 to B7-1 on the T-cell surface results in an inhibitory signal and prevents T-cell activation. CTLA4:B7-1 interaction is an important drug target for the regulation of the host"s response to cancer. |