Cell-Penetrating Peptides (CPPs), also known as protein transduction domains (PTDs) or membrane transduction peptides (MTPs) have been widely used for the intracellular uptake and delivery of various macromolecules, or "cargo", which are associated with the peptides either via covalent bond or through non-covalent interaction, such as TAT family peptides. As an attractive pharmaceutical and biochemical tool, CPPs can overcome the impermeable nature of cell membrane to facilitate the cellular penetration of potential drugs into mammalian cells. Applications of cell-penetrating peptides for delivering various macromolecules with biological functions into cells begin to come into vogue.
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